Thermoplastic PMMA is typically processed at 240–250 °C. All common molding processes may be used, including injection molding, compression molding and extrusion. The highest quality PMMA sheets are produced by cell casting, but in this case, the polymerization and molding steps occur concurrently. The strength of the material is higher than molding grades owing to its extremely high molecular mass. Rubber toughening has been used to increase the strength of PMMA owing to its brittle behavior in response to applied loads.

PMMA can be joined using cyanoacrylate cement (so-called "Superglue"), with heat (melting), or by using solvents such as di- or trichloromethane to dissolve the plastic at the joint which then fuses and sets, forming an almost invisible weld.

Scratches may easily be removed by polishing or by heating the surface of the material.

Laser cutting may be used to form intricate designs from PMMA sheets. PMMA vaporises to gaseous compounds (including its monomers) upon laser cutting, so a very clean cut is made, and cutting is performed very easily. In this respect PMMA has an advantage over competing polymers such as polystyrene and polycarbonate, which require higher laser powers and give more messy and charred laser cuts.

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